60 Billion CFU SBO Probiotic

Bacillus subtilis:  A resilient, spore-forming bacteria highly studied for its support of intestinal barrier function and interaction with Lactobacillus species to support both digestive and immune health. B. subtilis also exerts direct opposition to potentially harmful bacteria in the gut^4,9,10,13 . 

Lactobacillus plantarum:  A widely used probiotic strain, L. plantarum is backed by research suggesting its benefits for digestive, immune, and brain health^6,11 . 

Bacillus coagulans:  One of the most used spore-based species in probiotic supplements, B. coagulans assist Lactobacillus species to support a balanced microbiome and improve digestive health¹². 

Saccharomyces boulardii:  As a yeast-based microbe closely related to baker’s yeast and rising in scientific interest, S. boulardii demonstrates strong survival abilities and wide benefits for human health¹³ . 

Lactobacillus paracasei:  This friendly, native lactic-acid producing bacteria demonstrates multi-factorial benefits for nutrient metabolism, gut health, and immune function^11,12 . 

Bacillus clausii:  Well-documented for its robust survival in harsh, acidic, and high-temperature environments, B. clausii also shows evidence of its important role in balancing the human microbiome to support a healthy immune system and improve gut function^15,16 . 

Organic apple cider vinegar:  Pure, unfiltered, non-GMO, and organic apple cider vinegar has been used for centuries in traditional medicine in support of healthy digestion with evidence of its efficacy for weight management¹⁷ . 

Fermented ginger root:  Ginger root alone provides a source of prebiotic fiber for the microbiome and contains several bioactive compounds that support gut and immune health. Fermentation further amplifies the powerful benefits of this ingredient^18,19 . 

Fermented barley leaf:  Friendly gut bacteria transform the nutritive plant fiber from barley grass into important short-chain fatty acids that support the intestinal barrier. Uniquely, fermented barley also retains water to promote optimal digestion and bowel function²⁰ . 

Bamboo stem and leaf extract:  Research suggests that the various plant parts of bamboo contain phytochemicals that provide cellular protection from free radical damage. Bamboo is also a rich source of silica, a nutrient that plays a role in collagen synthesis to support gastrointestinal function^21,22 

1. Hong HA, To E., Fakhry S, et al. Defining the Natural Habitat of Bacillus Spore-Formers. Research in Microbiology. 2009;160(6):375-379.
2. Ritchie ML, Romanuk TN. A Meta-Analysis of Probiotic Efficacy for Gastrointestinal Diseases. PloS One. 2012;7(4):e34938.
3. Bernardeau M, Lehtinen MJ, Forssten SD, Nurminen P. Importance of the Gastrointestinal Life Cycle of Bacillus for Probiotic Functionality. Journal of Food Science and Technology. 2017;54(8):2570-2584.
4. McFarlin BK, Henning AL, Bowman EM, et al. Oral Spore-Based Probiotic Supplementation Was Associated with Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers. World Journal of Gastrointestinal Pathophysiology. 2017;8(3):117.
5. Galdeano CM, Cazorla SI, Dumit JML, et al. Beneficial Effects of Probiotic Consumption on the Immune System. Annals of Nutrition and Metabolism. 2019;74(2):115-124.
6. Liu YW, Liong MT, Tsai YC. New perspectives of Lactobacillus plantarum as a probiotic: The gutheart-brain axis. Journal of Microbiology. 2018;56(9):601-613.
7. Bermúdez-Humarán LG, Salinas E, Ortiz GG, et al. From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis. Nutrients. 2019;11(4):890.
8. Yu T, Kong J, Zhang L, et al. New Crosstalk Between Probiotics Lactobacillus plantarum and Bacillus subtilis. Scientific Reports. 2019;9(1):1-9.
9. Kimelman H, Shemesh M. Probiotic Bifunctionality of Bacillus subtilis—Rescuing Lactic Acid Bacteria from Desiccation and Antagonizing Pathogenic Staphylococcus aureus. Microorganisms. 2019;7(10):407.
10. Rhayat L, Maresca M, Nicoletti C, et al. Effect of Bacillus subtilis Strains on Intestinal Barrier Function and Inflammatory Response. Frontiers in Immunology. 2019;10:564.
11. Håkansson A, Andrén Aronsson C, Brundin C, et al. Effects of Lactobacillus plantarum and Lactobacillus paracasei on the Peripheral Immune Response in Children with Celiac Disease Autoimmunity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2019;11(8):1925.
12. Adibpour N, Hosseininezhad M, Pahlevanlo A, Hussain MA. A Review on Bacillus coagulans as a Spore-Forming Probiotic. Applied Food Biotechnology. 2019;6(2):91-100.
13. McFarland LV. Systematic Review and Meta-Analysis of Saccharomyces boulardii in Adult Patients. World Journal of Gastroenterology. 2010;16(18):2202.
14. Chiang SS, Pan TM. Beneficial Effects of Lactobacillus paracasei subsp. paracasei NTU 101 and its Fermented Products. Applied Microbiology and Biotechnology. 2012;93(3):903-916.
15. Urdaci MC, Bressollier P, Pinchuk I. Bacillus clausii Probiotic Strains: Antimicrobial and Immunomodulatory Activities. Journal of Clinical Gastroenterology. 2004;38:S86-S90.
16. Ghelardi E, Celandroni F, Salvetti S, et al. Survival and Persistence of Bacillus clausii in the Human Gastrointestinal Tract Following Oral Administration as Spore‐Based Probiotic Formulation. Journal of Applied Microbiology. 2015;119(2):552-559.
17. Khezri SS, Saidpour A, Hosseinzadeh N, Amiri Z. Beneficial Effects of Apple Cider Vinegar on Weight Management, Visceral Adiposity Index and Lipid Profile in Overweight or Obese Subjects Receiving Restricted Calorie Diet: A Randomized Clinical Trial. Journal of Functional Foods. 2018;43:95-102. 
18. Wang J, Chen Y, Hu X, et al. Assessing the Effects of Ginger Extract on Polyphenol Profiles and the Subsequent Impact on the Fecal Microbiota by Simulating Digestion and Fermentation In Vitro. Nutrients. 2020;12(10):3194.
19. Kayath CA, Ibala Zamba A, Mokémiabeka SN, et al. Synergic Involvements of Microorganisms in the Biomedical Increase of Polyphenols and Flavonoids during the Fermentation of Ginger Juice. International Journal of Microbiology. 2020; Article ID 8417693.
20. Bamba T, Kanauchi O, Andoh A, Fujiyama Y. A New Prebiotic from Germinated Barley for Nutraceutical Treatment of Ulcerative Colitis. Journal of Gastroenterology and Hepatology. 2002;17(8):818-824.
21. Nirmala C, Bisht MS, Bajwa HK, Santosh O. Bamboo: A Rich Source of Natural Antioxidants and its Applications in the Food and Pharmaceutical Industry. Trends in Food Science & Technology. 2018;77:91-99.
22. Nielsen FH. Update on the Possible Nutritional Importance of Silicon. J Trace Elem Med Biol. 2014;28(4):379-82.